Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol
Received 11 July 2003; accepted 22 September 2003.
Abstract
We examined the effect of Helicobacter pylori (H. pylori) eradication on lipids and apolipoproteins in 87 patients with duodenal ulcers. A significant increase was observed in high-density lipoprotein (HDL) cholesterol (+24.7%, p <0.001), apolipoprotein AI (+9.0%, p <0.001), and apolipoprotein AII (+11.7%, p <0.001) after eradication. Minor increases occurred in total cholesterol, triglycerides, and apolipoprotein B, whereas low-density lipoprotein cholesterol remained unchanged. Our results suggest that chronic H. pylori infection reduces plasma levels of HDL cholesterol and that eradication improves the lipoprotein pattern.
aClinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, University of Graz, Graz, Austria
bInstitute of Medical Microbiology and Hygiene, Freiburg, Germany
cDivision of Clinical Chemistry, Department of Medicine, University of Freiburg, Freiburg, Germany
dDepartment of Internal Medicine II—Cardiology, University of Ulm, Ulm, Germany
Dr. Scharnagl's address is: Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, Auenbrugger Platz 15, A-8036 Graz, Austria.
ABSTRACT